Imran Ali, Mohd. Suhail, Mohd. Fazil, Bilal Ahmad, Ahmad Sayeed, Mohd Farooq Naqshbandi and Amir Azam
All around the world, the percentage of deaths due to cancer is continuously increasing-the greatest devastation of deaths. Among all medications, Unani medicines are boon for human beings to treat cancer with no or least side effects. About 80% rural population use natural products for primary health care. Cuscuta reflexa Roxb. (family Cuscutaceae) is utilized in traditional medicines for curing cancer and other diseases, and it is considered as the most significant plant in the Unani medicinal system. The extracts of Cuscuta reflexa Roxb. were obtained to measure the anticancer activity with H-1299 and MCF-7 cancer cell lines. Soxhlet extraction was utilized for stem and seeds. The anticancer activity of fractions of each extract obtained by using Flash chromatography was also checked. Besides, the antioxidant activity of each fraction was also checked. DNA binding study supported the results obtained during whole process. The cellular death was detected utilizing ELISA. The results indicated that extracts of Cuscuta reflexa Roxb. exhibited strong anticancer activities as compared to the fractions of each extract. Cuscuta reflexa Roxb. extracts indicated noteworthy cytotoxicity against human H-1299 and (lung cancer) MCF-7 cancer cells (breast cancer). The extract of this plant may be given to the patients having lung cancer and breast cancer.
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