Revista estadounidense de administración avanzada de fármacos Acceso abierto

Abstracto

Cytotoxic Activity of Sulphonamide with Selenium to Decrease Raised Lipid Profile in the Treatment Hepatocarcinogenesis

Ritu Gupta, Firoz Anwar and R.L.Khosa

Aim: The aim of this study was to investigate the cytotoxic activity of sulfamethoxazole hydrochloride (30mg/kg) with Selenium in the form of sodium selenite (Na2SeO3) (4mg/kg) orally on lipid parameter in the treatment of hepatocarcinogenesis.

Materials and Methods: Wistar rats were divided into 7 groups and 6 animals in each group: Group 1control group (normal saline), Group 2 positive control (DEN), Group 3 (positive control for SMX), Group 4 (positive control for sodium selenite), Group5 (positive control for SMX + Se combination) Group 6 (post SMX + Se) (THR) Group7 (Pre SMX + Se) (PRH). Single intraperitoneal administration of chemical carcinogen diethylnitrosamine (DEN) (150 mg/ kg) in single dose elevated the levels of total cholesterol, triglycerides and the HDL level was decreased in the DENadministered animals of group 2 when compared to group 1animals.

Results: The levels of Total cholesterol and Triglycerides were significantly elevated and the serum HDL level was decreased in the DEN-administered animals of group II when compared to group 1 animals. These parameters were maintained to normal by the treatment of (SMX+SE) in the group 6, group 7 and group 5 control groups.

Conclusion: The study result suggests that at a reduced dose of combination of sulfamethoxazole and sodium selenite at doses 30mg/kg and 4mg/kg can act as chemopreventive agent in DEN induced Hepatocarcinoma.