Vinay Umesh Rao, P.Sai Sruthi, M. Sudhakar, K.Kishore Kumar
Zolpidem tartarate (ZT) is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation. The objective of this research was to prepare oral dissolving films (ODF) containing ZT. Different combinations of polymers and plasticizers were evaluated for optimizing the physical properties and the in vitro drug release. Films were prepared and subjected to various physicochemical evaluations and in vitro dissolution studies. The film prepared using HPMC E15 (F4) with 1:1 ratio of drug and polymer with glycerol as plasticizer were considered to have acceptable physical properties, disintegration time of below 60 seconds and > 85% of drug release within 5 minutes and hence were considered as optimum.
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