Revista estadounidense de administración avanzada de fármacos Acceso abierto

Abstracto

Effect of Permeation Enhancers on Diffusion of Lamotrigine Drug through Cellophane Membrane

Vinay Rao, M.Kalyan Raj, S.Ravinder, K.Sowmya, K.Praveen Kumar, M.Sudhakar

The effect of 3 different categories of permeation enhancers on the in vitro permeation of Lamotrigine across cellophane membrane were evaluated using vertical type Franz Diffusion Cell. This work was conducted as a permeation enhancer screening study for development of Lamotrigine Transdermal Drug Delivery System. Dimethyl Sulfoxide (DMSO) at 5% v/v and Tween 80 at 0.1% v/v gave a 6 and 7 folds enhancement in permeation values respectively. SLS and Peppermint Oil did not show any enhancement in the penetration.