Revista de bioquímica y biología molecular Acceso abierto

Abstracto

Evaluation of Ketoprofen Effect on Oxidative Stressed Mice

Benkhassi Zoubair*, Loutfi Mohammed, Benaji Brahim, Mostafa kabine, Bourhim Noureddine

Ketoprofen one of the propionic acid classes of Nonsteroidal Anti-Inflammatory Drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin it was patented in 1967 and approved for medical use in 1980. Ketoprofen is widely used for the treatment of pains, fever and inflammation is generally prescribed for arthritis related inflammatory pains or severe toothaches that result in the inflammation of the gums. Ketoprofen topical patches are being used for treatment of musculoskeletal pain. This study designed to evaluate if Ketoprofen has an antioxidant effect, relative to its analgesic, antipyretic and anti-inflammatory activities. Oxidative stress was induced by intraperetoneal injection of Hydrogen Peroxide (H₂O₂), and then a comparative study is made concerning the activities of the antioxidant enzymes Catalase (CAT), Superoxide Dismutase (SOD), Gluthation Reductase (GR), Succinate Dehydrogenase (SDH), and index of lipid peroxidation: Thiobarbituriquc Acid Reactive Substances (TBARS); compared to the group treated by L-ascorbic acid star of antioxidant and group ascorbic acid+H₂O₂, These results are statistically significant to conclude that NSAID drug Ketoprofen showed a strong antioxidant effect and protective effect against oxidative stress induced by H₂O₂ in comparison with the effect of ascorbic acid (vitamin C).