Sudhir. Maddela, Eswar Gupta. Maddi and Ramarao. Nadendla
Valsartan is a BCS class II antihypertensive drug whose bioavailability is dissolution rate limited. Various capsule formulations of valsartan were prepared using micro crystalline cellulose and sodium lauryl sulfate. Their dissolution profiles were compared with commercial marketed formulations. Formulation J was found to have similar t90 values to marketed brands statistically. Influence of sodium lauryl sulfate on the solubility of valsartan was studied and was found to increase with the concentration of sodium lauryl sulfate. Compatibility of valsartan with micro crystalline cellulose and sodium lauryl sulfate was studied by non-thermal methods like HPLC and IR.
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