Revista estadounidense de administración avanzada de fármacos Acceso abierto

Abstracto

Preparation and Evaluation of Mucoadhesive Microspheres of Simvastatin by Ionic Gelation Technique

D. Srinivasa Rao, S. Haranadh Reddy, S. Ramu and E. Rambabu

A primary object of using mucoadhesive formulations orally would achieve a substantial increase in the length of stay of the drug in GI tract stability problem in the intestinal fluid can be improved. Mucoadhesive microsphere carrier systems were made from the biodegradable polymers in sustained drug delivery. The objective of the present study is related to the preparation and evaluation of mucoadhesive microspheres of simvastatin by using different polymers like Sodium alginate, HPMC K100M, Sodium CMC, Ethyl cellulose, Methyl cellulose, Guar gum, Xanthan gum and Carbopol 940 in different ratios by the Ionic deletion method. The prepared batches of mucoadhesive microspheres of simvastatin were evaluated for the flow properties; drug content, entrapment efficiency, and Percent mucoadhesive property, in vitro dissolution studies of all 12 formulations were performed. From the all batches F10 (Drug: Sod. Alginate: Methyl cellulose 1:2:1) batch is considered to be the most promising formulation batch because among all the batches it shows better extent of drug release 97.11% (8hrs), good entrapment efficiency (78%), and in vitro wash-off test shows the good mucoadhesive property. Simvastatin release from alginate – Methyl cellulose (F10) was slow and extended over a period of 8 hrs and these microspheres were found suitable for the oral controlled release formulation.