Agnieszka Grabinska, Lukasz Michalczyk, Anna Grabinska, Tomasz Syrylo, Tomasz Zabkowski
Introduction: Fournier’s Gangrene (FG) is a devastating necrotising disease that affects the perineum and genitourinary regions. The aim of this study is to identify pathogens whose growth was associated with FG and their antibiotic sensitivity/resistance patterns based on bacterial culture; in addition, this study investigated the relationship between causative pathogens and prognostic factors and mortality.
Materials and methods: It was a retrospective study of 35 patients who were treated for fournier's gangrene in the period from 2017 to 2022. The study group consisted only of male persons (n=35) aged 24-85 years. Demographic data were evaluated and their relationship with causative pathogens, as well as their impact on antibiotic sensitivity and resistance patterns, were investigated.
Results: The most common microbiology involved in FG is polymicrobial infection (54%) and the most common found pathogen isolate is Escherichia coli (32.6%) In the cultures of the gangrene material bacteria were detected: Escherichia coli in 14 (32.6%) people, Enterococcus faecalis in 6 (14%) people and Pseudomonas aeruginosa in 5 (11.6%) people.
Most bacteria were sensitive to piperacillin-tazobactam, clindamycin and metronidazole and resistant to cefuroximum, ciprofloxacin and ceftriaxone.
Conclusions: Causative pathogens in FG are shifting; thus, empirical antibiotic treatment for this disease should be modified.
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