Deepak Chandra, Uma Nath Tripathi, Shalini Srivastava and Amit Swaroop
The present study has been designed to evaluate the duration dependent protective effect of aqueous extract of Momordica charantia (MC) and vitamin C against carbofuran (CF) toxicity in liver and kidney tissues of mice. The level of malondialdehyde (MDA), and the activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) contents were studied in the liver and kidney tissues. The data showed MDA levels were increased significantly in the CF treated group in 1 and 2 months exposure. But the effect was attenuated by the treatment of MC and vitamin C. The contents of GSH were decreased significantly in the CF treated group in 1 and 2 months exposure. But after treatment GSH contents were increased significantly in MC and vitamin C treated groups. The activities of antioxidant enzymes (SOD and CAT) were also decreased significantly in both the tissues of CF treated group. After treatment with MC and vitamin C activities were significantly increased. These results suggest that the administration of aqueous extract MC and Vitamin C could diminish the adverse effects of carbofuran on lipid peroxidation and activities of antioxidant enzymes in mice.
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