H. Serag, G. Edrees
The present work was to elucidate the effectiveness of orally administered chitosan-Cu complex (200 mg/kg b.wt.) as a prophylactic agent against some harmful disturbances in mice orally treated freshly prepared dibutylnitrozamine (DBNA) (NaNO2 + DBA, 2000 ppm & 1000 ppm respectively) for 12 weeks. DBNA resulted in dramatic decrease in T3 and T4 levels, accompanied by decline in serum total protein, albumin and globulin concentration. In addition total leukocytes and neutrophils remarkably decline, parallel with exceed in lymphocytes and serum total lipid. Also, the total body weight negatively affected. However, most of these noteworthy effects of DBNA were suppressed by chitosan-Cu complex pretreatment indicating its protective role against various metabolic alterations caused by DBNA.
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